Adolescence is a transitional stage of physical and psychological development that generally occurs during the period from puberty to legal adulthood. This is a vital part of life. This is also a very critical period of life. In adolescent girls and boys both are floating in a colorful and fantasy world. So everything seems colorful to them. That’s why they may go astray. Adolescence is a time of risks. Unlimited freedom brings disasters for them. They rush to the path of destruction without knowing the consequence. Adolescent is a young person who is developing from a child to an adult. Adolescents are vulnerable to various diseases. They may be addicted to alcohol, cigarettes and other drugs which may cause them deadly diseases. They are also in danger of sexual relationship which will lead them to intentional and unintentional injuries, unintended pregnancies, and sexually transmitted infections including Human Immunodeficiency Virus popularly known as HIV. Many of them also face a wide range of adjustment and mental health problems. That is why, it is necessary to be very careful about the diseases that can be life threatening. It is essential to teach them that addiction to alcohol, cigarettes and other drugs may destroy their life. Moreover, they should be given religious teaching besides general education about physical relationships. They should be practical examples of what may happen due to unsafe sexual relationships.